Prognostic factors influencing fresh and frozen IVF outcomes: an analysis of the UK national database.

作者:

Hirst, W. Mark¹
Vail, Andy¹
Brison, Daniel R.²
Roberts, Stephen A.¹ steve.roberts@manchester.ac.uk

資料來源:

Reproductive BioMedicine Online; May2011, Vol. 22 Issue 5, p437-448, 12p

文件類型:

Article

主題術語:

*FERTILIZATION in vitro, Human
*FERTILITY, Human
*MULTIPLE pregnancy
*HUMAN reproductive technology

地理詞彙:

GREAT Britain

作者提供的關鍵字:

cohort
in-vitro fertilization
outcomes
prognostic factors
statistical models

NAICS/Industry Codes:

325413 In-Vitro Diagnostic Substance Manufacturing

摘要:

National registry data provides a valuable resource to quantify factors which influence the outcomes of IVF treatments. Multilevel logistic regression analyses for live birth and multiple births given a live birth were undertaken using data from the UK Human Fertilization and Embryology Authority's registry of treatments conducted between 2000 and 2005. This study analysed 119,930 fresh and 19,918 frozen transfers from 85,349 patients in 84 centres. As well as quantifying the effects of a range of previously identified prognostic factors, the analyses showed that embryo cryopreservation reduced the live birth rate substantially (odds ratio (OR) 0.60, 95% confidence interval (CI) 0.57-0.64) compared with typical fresh cycles. Prognostic factors for transfers following cryopreservation were largely similar to those for fresh cycles, with some evidence that female age is less important, and there were small differences in the effects of the numbers of embryos transferred and previous IVF attempts that can be ascribed to selection effects. No factors were identified which specifically predicted twin outcomes; patients with a high twin risk were those with a high chance of treatment success. After allowing for all prognostic factors, there remained clinically important variability between centres (median OR 1.4) and between patients (median OR 1.8). [ABSTRACT FROM AUTHOR]

 

Copyright of Reproductive BioMedicine Online is the property of Reproductive Healthcare Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

作者所屬機構:

¹Health Sciences-Methodology, Manchester Academic Health Science Centre (MAHSC), University of Manchester, Manchester M13 9WL, UK
²Manchester Academic Health Science Centre (MAHSC), University of Manchester, Department of Reproductive Medicine, St. Mary's Hospital, Manchester, Central Manchester NHS Foundation Trust, UK

ISSN:

14726483

DOI:

10.1016/j.rbmo.2010.12.008

入藏號碼:

60844908

資料庫:

Academic Search Complete